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Dr. Heckman directs a research laboratory working with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, and pharmacological approaches. The key goal of these studies is to develop new approaches towards therapeutic strategies in human patients. To aid this objective, reflex pathways that can be studied in human patients are also studied in animal models, including the H-reflex, stretch reflex, tendon vibration reflex and flexion/withdrawal reflex.
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A key resource available for these studies is a 6 degrees-of-freedom robotic arm that is used to make limb movements that are similar to those applied to human subjects. Studies of the cellular mechanisms of reflexes and inputs generated by these limb movements in various animal models of neurotrauma and neurodegeneration suggest a diverse set of new rehabilitation strategies, ranging from specific limb manipulations to new pharmacologic agents.
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Dr. Hornby directs the Neurolocomotion Laboratory where the focus of ongoing studies is to determine how various physical and pharmacological interventions alter volitional motor control in individuals with spinal cord injury and stroke. He utilizes quantitative physiological, biomechanical and clinical measures to determine the mechanisms underlying alteration in motor function through recovery and rehabilitation. Techniques employed include those utilized in the animal models, including H-, stretch, vibration and flexor withdrawal reflexes, corticomotoneuronal integrity using transcranial magnetic stimulation, as well as single and mutltijoint torques during static and dynamic conditions. Electromyographic activity and kinematic patterns are collected during and following volitional and reflex activity, with an emphasis on locomotor function. Cardiopulmonary measures, such as oxygen consumption and electrocardiographic activity, also help elucidate the extent of physiological improvements during our interventions.
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In summary, our infrastructure can be considered to support a novel approach towards career development and an idea factory for rehabilitation scientists. Thus, we have established collaborations with investigators around the country.
